Collect. Czech. Chem. Commun. 1986, 51, 1187-1194

Alkaline hydrolysis of methyl hydrogen malonate in water-organic solvents

Oľga Grančičová, Vladislav Holba and Ľudmila Beluská

Department of Physical Chemistry, Faculty of Natural Sciences, Comenius University, 842 15 Bratislava


Kinetics of alkaline hydrolysis of methyl hydrogen malonate in water-methanol, water-dioxane, water-tert-butyl alcohol and water-ethylene glycol mixtures was examined. The valuse of the transfer functions of the activated complex δmμ from water to the first two mixed media were calculated from the measured solubilities of tetrabutylammonium hydrogen malonate, the activation Gibbs energies and the known values of transfer functions for tetrabutylammonium and hydroxide ions. Some conclusions concerning the effect of a nonaqueous component of the solvent on solvation of the reactants and the activated complex have been drawn from the experimental data obtained.