Collect. Czech. Chem. Commun. 1986, 51, 872-878

Synthesis of 16-(4-iodophenyl)hexadecanoic acid

Jiří Protiva, Jaroslav Pecka, Eva Klinotová and Miloš Procházka

Department of Organic Chemistry, Charles University, 128 40 Prague 2


16-(4-Iodophenyl)hexadecanoic acid was prepared in six steps by two methods: from 6-(2-thienyl) hexanoic acid and 6-phenylhexanoyl chloride or by alkylation, or acylation, of 2-thienylthiophene. Mass and 1H NMR spectra of some prepared compounds are discussed. The synthesis is suitable for preparation of radioactively labelled acids used as myocardial imaging agents.