Collect. Czech. Chem. Commun. 1986, 51, 2909-2918

Synthesis of blood serum thymic factor and its analogs

Martin Černýa, Evžen Kasafírekb, Jozef Rovenskýc and Jiří Křepelkab

a Institute of Criminology, 110 01 Prague 1
b Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
c Research Institute of Rheumatic Diseases, 921 01 Piestany


The blood serum thymic factor (FTS) and its two analogs (desGlp1)-FTS and (Gln1)-FTS were synthesized by a novel procedure. The biological activity of these compounds was assayed by the E-rosette test. The activity of (desGlp1)-FTS is decreased and (Gln1)-FTS shows an inhibitory effect.