Collect. Czech. Chem. Commun. 1986, 51, 2437-2443

Association of benflurone in aqueous solutions studied by measuring the activity of chloride ions

František Kopeckýa, Mária Vojtekováa and Milan Pešákb

a Department of Physical Chemistry, Pharmaceutical Faculty, Comenius University, 832 32 Bratislava
b Research Institute of Pharmacy and Biochemistry, 130 60 Prague 3


The conventional activity of chloride ions was measured by an ion-selective electrode at 25 °C in aqueous solutions of benflurone, i.e. 5-(2-(N,N-dimethylamino)ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride, without or with additions of KCl. These results suggest a gradual association of benflurone; the formation of a hetero-associate, (BH+)2Cl-, followed by higher associates was evaluated in the measured range up to 0.1 mol l-1.