Collect. Czech. Chem. Commun. 1986, 51, 2207-2213
https://doi.org/10.1135/cccc19862207

Direct esterification of α-methoxy-α-(trifluoromethyl)phenylacetic acid

Ludvík Streinz, Irena Valterová, Zdeněk Wimmer, Miloš Buděšínský, David Šaman, Jitka Kohoutová, Miroslav Romaňuk and Jan Vrkoč

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6

Abstract

Esters of α-methoxy-α-(trifluoromethyl)phenylacetic acid (Mosher acid, MTPA) were prepared in good yields from alcohols and the free acid Ia using 2-chloro-1-methylpyridinium iodide (II) as condensing agent.