Collect. Czech. Chem. Commun. 1986, 51, 34-44

Possibility of determination of some derivatives of pterin important in the diagnostics of malignant tumours by using differential pulse polarography

Václav Kočmída, Miroslav Podoláka, Jiří Čoupeka and Oskar Andrýsekb

a Laboratory Instruments Works, 162 03 Prague 6
b Institute of Biophysics and Nuclear Medicine, Charles University, 120 00 Prague 2


The polarographic behaviour of 6,7-dimethylpterin, xanthopterin, 6-pterinaldehyde, neopterin and 6-hydroxymethylpterin was investigated. These compounds are suitably determined by employing differential pulse polarography; some results suggest the possibility of their determination by cathodic stripping voltammetry with adsorptive accumulation. For all compounds, the effect of pH on polarographic reduction was examined. Under optimal conditions, the calibration curve of all compounds under investigation was linear in the range 2 . 10-6 - 1 . 10-7 mol/l and the detection limit was below 1 . 10-7 mol/l.