Collect. Czech. Chem. Commun. 1985, 50, 1959-1961

Alkylating activity of polyphosphate ester in the course of the synthesis of benzimidazoles

Giovanni Allunni Bistocchia, Giovanni De Meoa, Mauro Pedinia, Adolfo Riccia and Pierre Jacquignonb

a Instituto di Chimica, Facolta di Medicina e Chirurgia, Universita Degli Studi. 06100 Perugia, Italia
b Institut de Chimie des Substances Naturelles du C.N.R.S., 91190 Gif-sur-Yvette, France


5-Fluoro-2-(5-nitrofuryl)benzimidazole (I) was synthesized from 4-fluoro-1,2-diaminobenzene and 5-nitro-2-furoic acid using ethyl polyphosphate as cyclization reagent. N-Ethyl derivative was isolated as by-product in substantial amount.