Collect. Czech. Chem. Commun. 1985, 50, 1862-1869

Cyclocondensation reactions of 3-aryl-2-benzylidene-3-oxopropanenitriles with acetylaromatic derivatives

Štefan Marchalín and Josef Kuthan

Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6


Cyclocondensation of 3-aryl-2-benzylidene-3-oxopropanenitriles Ia and Ib with acetyl aromatic derivatives IIa-IIc in the presence of ammonium acetate affords 2,6-diaryl-4-phenyl-3-cyanopyridines IV and V. Reaction of the nitrile Ib with 1,2-diphenylethanone (III) gave 2-(4-biphenylyl)-4,5,6-triphenyl-3-cyanopyridine (VI). The relation between the structure of the synthesized pyridine derivatives IV-VI and their spectral properties is discussed.