Collect. Czech. Chem. Commun. 1985, 50, 1244-1248

Homogeneous hydrogenolysis of the C-I bond; Preparation of [5-2H]uracil

Josef Roček, Vladimír Sváta and Ladislav Lešetický

Department of Organic Chemistry, Charles University, 128 40 Prague 2


Reductive dehalogenation of 5-iodouracil by deuterium, catalysed by coordination compounds of transition metals, has been studied. Conditions were found under which the deuteration product contained 80% of [5-2H]uracil and less than 2% of [5,6-2H2]uracil.