Collect. Czech. Chem. Commun. 1985, 50, 1064-1069

Synthesis of 7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-1,4-benzodiazepin-2-one

Zdeněk Vejdělek, Zdeněk Polívka and Miroslav Protiva

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


The synthesis of the title compound II was carried out from 5-chloro-3-(4-chlorophenyl)-2,1-benzisoxazole (III) by two methods proceeding via new intermediates V and VI. 5-(2-Fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one (VII) was synthesized from 2-amino-2'-fluorobenzophenone via VIII.