Collect. Czech. Chem. Commun. 1985, 50, 482-491

Semisynthetic cephalosporins. The synthesis of 7-(heteroarylacetamido)-3-acetoxycephalosporanic acids

Ľubomír Jandaa, Zdeno Votickýb, Ján Šipoša and Marta Múčkováa

a Drug Research Institute, Modra, 811 04 Bratislava
b Institute of Chemistry, Slovak Academy of Sciences, 842 38 Bratislava


7-(5-(5-Aryl-2-furyl)-1- and -2-tetrazolylacetamido)cephalosporanic acids and their sodium salts were prepared by N-acylation of 7-aminocephalosporanic acid with derivatives of 5-(5-aryl-2-furyl)-1- and -2-tetrazolylacetic acids. The final products tested in vitro on the Gram-positive and Gram-negative strains of microorganisms showed an activity comparable or better than that of reference substances.