Collect. Czech. Chem. Commun. 1985, 50, 2625-2633
https://doi.org/10.1135/cccc19852625

7-O-Alkenyl and alkynyl derivatives of daunomycinone

Věra Přikrylová, Petr Sedmera, Josef V. Jizba, Jindřich Vokoun, Helena Lipavská, Miloslav Podojil and Zdenko Vaněk

Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4

Abstract

Reaction of daunomycinone (I) with unsaturated alcohols and p-toluenesulfonic acid produces a mixture of 7(S)-O- and 7(R)-O-alkenyl or alkynyl derivatives II, III, VI-XVII. With daunomycinone and 2-methyl-2-propen-1-ol, the ketals IV and V are formed.