Collect. Czech. Chem. Commun. 1985, 50, 2289-2298


Ružena Čižmárikováa, Alois Borovanskýb, Ján Kozlovskýc, Eva Béderovác and Anna Dingovác

a Department of Inorganic and Organic Chemistry
b Department of Pharmaceutical Chemistry
c Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, 832 32 Bratislava


A series of new beta-adrenolytics derived from p-hydroxyacetophenone was synthesized by four methods. The most advantageous was found to be the five-step synthesis via reaction of the intermediate oxirane with amines. The selected compounds reveal a beta-adrenolytic and antiarrhythmic activities.