Collect. Czech. Chem. Commun. 1984, 49, 1505-1514

Semisynthetic cephalosporines. The synthesis of some substituted tetrazolylacetic acids

Ľubomír Jandaa, Zdeno Votickýb, Jan Světlíka, Jaroslava Grimovác and Eva Maturovác

a Drug Research Institute, Modra 811 04 Bratislava
b Institute of Chemistry, Slovak Academy of Sciences, 842 38 Bratislava
c Research Institute for Pharmacy and Biochemistry, 130 60 Prague


5-[5-(Substituted phenyl)-2-furyl]-1-tetrazolylacetic acids were synthesized from ethyl 5-(substituted phenyl)-2-furylcarbamidoacetates and phosphorus pentachloride via the corresponding imidoyl chlorides, which gave with sodium azide the respective ethyl 5-[5-(substituted phenyl)-2-furyl]-1-tetrazolyl acetates. A positive antiinflammatory effect was found when testing the acids obtained by hydrolysis of the acetates prepared.