Collect. Czech. Chem. Commun. 1983, 48, 1597-1601

Preparation of optically active 3-cyclopentyl-3-methyl-2-azetidinone

Jan Hauer and Jan Šebenda

Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, 162 06 Prague 6


The resolution of 2-cyclopentyl-2-cyanopropanoic acid gave its enantiomers, which by esterification and hydrogenation were transformed into (+) and (-)-methyl-(3-amino-2-cyclopentyl-2-methyl)propanoate. Their cyclization yielded both enantiomers of 3-cyclopentyl-3-methyl-2-azetidinone.