Collect. Czech. Chem. Commun. 1983, 48, 1341-1351

Vasopressin analogues modified in positions 2, 3 and 8. Synthesis and biological effects

Ivo Bláhaa, Danuta Konopinskab and Milan Zaorala

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia
b Instytut Chemii Uniwersytetu Wroclawskiego, Wroclaw, Poland


Four vasopressin analogues, modified in positions 2, 3 and 8 were prepared by solid phase as well as solution synthesis. Analogues, containing a D-amino acid in position 3, exhibit a low but markedly specific antidiuretic activity. Analogues with a D-substituent in position 2 show a more specific pressor activity.