Collect. Czech. Chem. Commun. 1983, 48, 3020-3023
https://doi.org/10.1135/cccc19833020

Depression of DNA synthesis in the thymus of zinc-treated adult mice

Alois Čiháka, Milagros Carcia Mesab and Hideo Inouec

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia
b Department of Pharmacology, National Center of Scientific Research, Havana 6990, Cuba
c Department of Biochemistry, School of Dentristy, Tokushima University, Tokushima 770, Japan

Abstract

Zn-ions in a high dose affect the uptake of thymidine into thymus DNA. The depression of DNA synthesis in the thymus of zinc-treated mice is dose-dependent and is more pronounced in adult than in young animals.