Collect. Czech. Chem. Commun.
1983, 48, 2862-2873
https://doi.org/10.1135/cccc19832862
Vasopressin analogues with effect on central nervous system: Synthesis and biological properties
František Brtníka, Ivan Krejčíb, Běla Kupkováb, Pavel Hrbasa, Jana Škopkováa, Tomislav Bartha and Karel Jošta
a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Research Institute for Pharmacy and Biochemistry, 194 09 Prague 9
Abstract
Synthesis of four vasopressin analogues which do not contain the glycinamine residue in position 9 and have a basic non-coded amino acid in position 8 is described. All the analogues exhibit very low endocrine activities and are effective in the passive avoidance test.
