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Collect. Czech. Chem. Commun. 1982, 47, 1856-1866
https://doi.org/10.1135/cccc19821856

Derivatives of benzo(c)fluorene: II. Synthesis and biological effect of basic ethers of 7-oxo-7H-benzo(c)fluorene

Jiří Křepelka, Iva Vančurová, Jiří Holubek, Milan Mělka and Karel Řežábek

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3

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  • Císař P., Nobilis M., Vybíralová Z., Holčapek M., Kolářová L., Pour M., Kuneš J., Klimeš J.: Disposition study of a new potential antineoplastic agent dimefluron in rats using high-performance liquid chromatography with ultraviolet and mass spectrometric detection. Journal of Pharmaceutical and Biomedical Analysis 2005, 37, 1059. <https://doi.org/10.1016/j.jpba.2004.09.031>
  • Hrubý Kamil, Anzenbacherová Eva, Anzenbacher Pavel, Nobilis Milan: Biotransformation of Benfluron by Rat Hepatic Cytochrome P450. Identification of Individual CYP-Enzymes Involved in Biotransformation of Benfluron, Prospective Antineoplastic Based on Benzo[c]fluorene. Collect. Czech. Chem. Commun. 2000, 65, 1374. <https://doi.org/10.1135/cccc20001374>
  • Svoboda Zbyněk, Nobilis Milan, Květina Jaroslav, Lemr Karel: Study of the Biotransformation of Benfluron Using the Isolated Perfused Rat Liver. Acta Med. (Hradec Kralove, Czech Repub.) 1999, 42, 73. <https://doi.org/10.14712/18059694.2019.146>
  • Nobilis Milan, Anzenbacher Pavel, Pastera Ji����, Svoboda Zbyn��k, Hrub�� Kamil, Kv��tina Jaroslav, Ubik Karel, Trejtnar Franti��ek: Study of the biotransformation of a potential benzo[c]fluorene antineoplastic using high-performance liquid chromatography with high-speed-scanning ultraviolet detection. Journal of Chromatography B: Biomedical Sciences and Applications 1996, 681, 143. <https://doi.org/10.1016/0378-4347(95)00523-4>
  • Miko Milan, Krepelka Jiri, Melka Milan: PRIMARY SCREENING AND INHIBITION OF MACROMOLECULAR BIOSYNTHESIS IN EHRLICH ASCITES CELLS BY BENZO(C)FLUORENE DERIVATIVES. Drug Metabolism and Drug Interactions 1991, 9, 1. <https://doi.org/10.1515/DMDI.1991.9.1.1>
  • Nobilis M., Kvasničková E., Šroler A., Hais I.M.: Elimination of Benfluron and its Metabolites in the Faeces and Urine of Rats. Drug Metabolism and Drug Interactions 1991, 9. <https://doi.org/10.1515/DMDI.1991.9.3-4.225>
  • Netopilová M., Veselá J., Dršata J.: Influence of 5-[2-(N,N-Dimethylamino)Ethoxy]-7-Oxo-7H-Benzo-(c)Fluorene Hydrochloride (Benflurone) on the Activity of Rat Liver Aspartate and Alanine Aminotransferases. Drug Metabolism and Drug Interactions 1991, 9. <https://doi.org/10.1515/DMDI.1991.9.3-4.301>
  • Hauser A., Thurner J.‐U., Hinzmann B.: Zur Übertragung von Substituenteneffekten in Fluorenen und Fluorenonen. J. Prakt. Chem. 1988, 330, 367. <https://doi.org/10.1002/prac.19883300306>
  • Nobilis Milan, Hais Ivo M.: Direct absorptiometric quantitation in high-performance liquid chromatography in the absence of concomitant reference standards. Journal of Chromatography B: Biomedical Sciences and Applications 1988, 434, 363. <https://doi.org/10.1016/S0378-4347(88)80003-3>
  • Lyčka Antonin, Jirman Josef, Nobilis Milan, Kvasničková Eva, Hais Ivo M.: Two‐dimensional 1H and 13C‐NMR spectra of 5‐(2‐dimethylaminoethoxy)‐7‐oxo‐7H‐benzo[c]fluorene, its precursor and metabolite. Magnetic Reson in Chemistry 1987, 25, 1054. <https://doi.org/10.1002/mrc.1260251207>
  • KREPELKA J., VANCUROVA E., HOLUBEK J., MELKA M., REZABEK K.: ChemInform Abstract: SUBSTANCES WITH ANTINEOPLASTIC ACTIVITY. LXXIX. DERIVATIVES OF BENZO(C)FLUORENE. II. SYNTHESIS AND BIOLOGICAL EFFECT OF BASIC ETHERS OF 7‐OXO‐7H‐BENZO(C)FLUORENE. Chemischer Informationsdienst 1982, 13. <https://doi.org/10.1002/chin.198248199>