Collect. Czech. Chem. Commun. 1982, 47, 1757-1761

2-Acylated derivatives of ergoline

Jan Beneš and Jiří Křepelka

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Reactions of ergoline derivatives Ia-VIIa with anhydrides of low-molecular-weight aliphatic acids, catalysed by boron trifluoride etherate, gave 2-acylated derivatives Ib-Id, IIb-IId, IIIb-Vb, or 1,2-diacylated derivatives VIb and VIIb. The compound IIb exhibited a hypotensive effect.