Collect. Czech. Chem. Commun. 1982, 47, 1636-1640

Wittig type reactions of 2-formylated derivatives of 6-methylergoline - I

Jan Beneš and Jiří Holubek

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Using the Horner-Wittig reaction, aldehydes I and II were converted, with high E-selectivity, into ethyl esters of substituted acrylic acids, VI and VII. The N-anions generated by deprotonation of derivative I-V with sodium hydride in tetrahydrofuran reacted with vinyltriphenylphosphonium bromide with the formation of derivatives of pyrrolo[1,2-a]ergoline-I, XI-XV.