Collect. Czech. Chem. Commun. 1982, 47, 1252-1257

Reactions of 4-aryl-1-methoxynaphtalene-2,3-dicarboxylic acid anhydrides and naphtho(2,3-c)furan-1-(3H)-one derivatives with hydrazines

Jiří Křepelka, Iva Vančurová and Jiří Holubek

Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3


Reactions of anhydrides of 4-aryl-1-methoxynaphthalene-2,3-dicarboxylic acids, Ia and Ib, with hydrazine hydrate gave derivatives of benzo(g)phthalazine, IV-VI. Analogous reactions of the compounds Ia and Ib with hydrazines IIIa and IIIb afforded the corresponoding N-aminoimides, VII-X. Derivatives of naphtho(2,3-c)furan-1(3H)-one, IIa-IIc, reacted with hydrazine hydrate with the formation of benzo(f)isoindoline-1(3H)-one derivatives, XI-XIII. In the antineoplastic screening the tested compounds have not proved efficacious.