Collect. Czech. Chem. Commun. 1982, 47, 1020-1025

Biosynthesis of mucidin, an antifungal antibiotic from basidiomycete Oudemansiella mucida 2H-, 13C-, and 14C-labelling study

František Neruda, Petr Sedmeraa, Zdeňka Zouchováa, Vladimír Musíleka and Miloslav Vondráčekb

a Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4
b Research Institute of Antibiotic and Biotransformations, 252 63 Roztoky near Prague


Incorporation of 2H-, 13C- and 14C-labelled precursors into mucidin (I) was studied by mass and 13C NMR spectroscopy and chemical degradations. Biosynthesis of I is connected with shiki-mate and acetate-malonate pathways. Methionine participates on the C- and O-methylation.