Collect. Czech. Chem. Commun. 1982, 47, 3432-3436

Derivatives of 3-(D-6-methyl-8β-ergolin-I-yl)propanoic acid

Miloš Beran, Jan Beneš and Jiří Křepelka

Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3


Amide I was prepared both by hydration of nitrile III under the conditions of ion pair extraction, and from nitrile III, via methyl ester IX, hydrazide X and azide XI. Ethyl ester XII and 2-hydroxyethyl ester XIII of acid VIII were also prepared. Amide I and nitrile III in rats have a lower antinidation and antilactation activity than corresponding lower homologues, i.e. amide II and nitrile XIV.