Collect. Czech. Chem. Commun. 1982, 47, 3160-3163

Sesquiterpenic lactones from Grossheimia macrocephala. Structure of grosheiminol

Włodzimierz Daniewskia, Andrzej Wawrzuńa, Ełżbieta Błoszykb, Bohdan Drożdżb and Miroslav Holubc

a Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw, Poland
b Department of Medicinal Plants, Academy of Medicine, Poznań, Poland
c Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia


From the leaves of Grossheimia macrocephala (MUSS.-PUSCHK.) D. SOSN. et TAKHT. cynaropicrin (II), isolipidiol (III) and the so far undescribed lactone grosheiminol (IV) were isolated in addition to grosheimin (I), detected in this species earlier. For grosheiminol the structure IV was derived, including relative and absolute configuration, on the basis of chemical correlation.