Collect. Czech. Chem. Commun. 1982, 47, 96-107

Synthesis of some isocardenolide analogs and 17β-maleimidoandrostane of westphalen structural type

Vladimír Pouzar, Pavel Drašar, Pavel Kočovský and Miroslav Havel

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


A series of analogs of cardiotonic steroids belonging to Westphalen structural type has been prepared. These compounds are derived from 17β-(2-maleimido)-5-methyl-19-nor-5β-androst-9-ene, (20E)-21-ethoxycarbonyl-5-methyl-19-nor-5β-pregna-9,20-diene and 5-methyl-19,21-dinor-5β-chola-9,22-dien-24-20-olide.