Collect. Czech. Chem. Commun. 1981, 46, 2263-2267

Resolution of S-benzyl-DL-penicillamine with penicillin amidohydrolase

Petr Šimeka, Tomislav Bartha, Miroslav Bártab, Vladimír Vojtíšekb and Karel Jošta

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Research Institute of Antibiotics and Biotransformations, 252 63 Roztoky


Racemic m-phenylacetyl-S-benzylpenicillamine was resolved into otical isomers by action of penicillin amidohydrolase (E.C. in high yield and optical purity.