Collect. Czech. Chem. Commun. 1981, 46, 2123-2128

The synthesis of model lactones of cyclolignan type

Jiří Křepelka and Jiří Holubek

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Lactones VI-IX were prepared on reduction of anhydrides of 4-aryl-1-methoxynaphthalene-2,3-dicarboxylic acids IV and V with sodium borohydride in methanol. Catalytic hydrogenation on platinum of lactones VIII and IX gave lactones with hydrogenated ring A, or A and C. Lactones XII and XIII were found to possess an inhibitory effect on the growth of the tumour S 37 in experimental animals.