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Collect. Czech. Chem. Commun. 1981, 46, 1199-1209
https://doi.org/10.1135/cccc19811199

Potential metabolites of the neuroleptic agent octoclothepin; Synthesis of 8-chloro-2,6-dihydroxy and 8-chloro-3,6-dihydroxy derivatives of 10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Miroslav Protiva, Zdeněk Šedivý, Josef Pomykáček, Emil Svátek and Jiří Holubek

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3

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  • Shirani Hamid, Bergman Jan, Janosik Tomasz: New syntheses of unsymmetrical thiepins and their selenium analogues. Tetrahedron 2009, 65, 8350. <https://doi.org/10.1016/j.tet.2009.08.014>
  • Protiva Miroslav: The place of dibenzo[b,f]thiepin derivatives in medicinal chemistry: Structures and activities. Journal of Heterocyclic Chem 1996, 33, 497. <https://doi.org/10.1002/jhet.5570330301>
  • Hands David, Marley Hugh, Skittrall Stephen J., Wright Stanley H. B., Verhoeven Thomas R.: The synthesis of 3‐hydroxymethyldibenzo[b,f]thiepin 5,5‐dioxide, a prostaglandin antagonist. Journal of Heterocyclic Chem 1986, 23, 1333. <https://doi.org/10.1002/jhet.5570230513>
  • PROTIVA M., SEDIVY Z., POMYKACEK J., SVATEK E., HOLUBEK J.: ChemInform Abstract: NEUROTROPIC AND PSYCHOTROPIC AGENTS. CL. POTENTIAL METABOLITES OF THE NEUROLEPTIC AGENT OCTOCLOTHEPIN; SYNTHESIS OF 8‐CHLORO‐2,6‐DIHYDROXY AND 8‐CHLORO‐3,6‐DIHYDROXY DERIVATIVES OF 10‐(4‐METHYLPIPERAZINO)‐10,11‐DIHYDRODIBENZO(B,F)THIEPIN. Chemischer Informationsdienst 1981, 12. <https://doi.org/10.1002/chin.198136268>