Collect. Czech. Chem. Commun. 1981, 46, 2935-2946

Synthetic utilization of α-amino-γ-bromobutyric acid in the preparation of non-coded amino acids; IR study of homoserine

Zdenko Procházka, Jorga Smolíková, Petr Maloň and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


α-Amino-γ-bromobutyric acid and its derivatives were utilized in the preparation of some non-coded (non-proteinogenic) amino acids and their derivatives. The bromine atom was replaced by hydrogen, hydroxyl, iodine and nitro, amino, and thiocyanato groups. Homolanthionine was prepared by two methods. Homoserine has been shown to exist in three crystalline modifications whose differences in the IR spectra indicate conformational changes.