Collect. Czech. Chem. Commun. 1981, 46, 2441-2445

The effect of some structural modifications of the oxytocin molecule on the duration of the galactogogic response

Tomislav Bartha, Jiřina Slaninováa, Linda Servítováa, Michal Lebla, Christine Kotsira-Engonopoulosb, Chrysa Tzougrakib, Iphigenia Photakib, Milan Krojidloa and Karel Jošta

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Laboratory of Organic Chemistry, The university of Athens, Athens 144, Greece


The duration of the galactogogic response to analogues of oxytocin, modified mainly in the aminoterminal part of the molecule, was determined in experiments with lactating rats. The influence of the individual structural modifications was investigated by determining the dependence of both the intensity of the effect and the total effect of the compound on the log dose.