Collect. Czech. Chem. Commun. 1981, 46, 2410-2420

Partial methylation of methyl 2,6-dideoxy-α-D-xylo- and α-D-lyxo-hexopyranoside

Jiří Jarý and Miroslav Marek

Laboratory of Monosaccharides, Prague Institute of Chemical Technology, 166 28 Prague 6


Rate of methylation of the hydroxyl groups in the title glycosides was investigated during their reaction with methyl iodide and sodium hydroxide in acetonitrile. Relative rate constants of the side-reactions and subsequent reactions taking place were calculated. The differences in the reaction rates of methylation of individual hydroxyl groups are discussed in connection with the possible polar and steric effects.