Collect. Czech. Chem. Commun. 1981, 46, 278-285

[7-Glycine]deamino-1-carba-vasopressin: Synthesis and pharmacological properties

František Brtník, Tomislav Barth and Karel Jošt

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


[8-Arginine]deamino-1-carba-vasopressin and its 7-glycine derivative were prepared by condensation of the amino-terminal, cyclic part of the molecule with carboxy-terminal tripeptide amides. Replacement of proline by glycine in the position 7 results in a substantial decrease in the vasopressin-like activities, the oxytocin-like activities remaining unchanged.