Collect. Czech. Chem. Commun. 1980, 45, 2524-2531

Aminolysis of N-acyllactams

Jaroslav Stehlíček and Jan Šebenda

Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, 162 06 Prague 6


The overall second-order rate constants of aminolysis of N-benzoyllactams of different ring size, the rate constants of aminolysis of N,N'-isophthaloyl- and N,N'-terephthaloylbis(6-hexanelactam) to the first and second stages and the ratio of splitting of the exocyclic and endocyclic amide bond by octylamine were determined in THF at 50 °C. The effect of the type of amine and medium on the rate of aminolysis was examined.