Collect. Czech. Chem. Commun. 1980, 45, 1595-1600


Jaroslav Slukaa, František Šmejkalb and Zdeněk Buděšínskýa

a Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3
b Research Institute of Antibiotics and Biotransformations, 252 63 Roztoky


On recation of cyclooctylamine with the sulfate of S-methylisothiourea cyclooctylguanidine was formed which was acylated with the methyl esters of 5-halogeno- and 3,5-dihalogeno-2-alkoxybenzoic acids. The 1-acyl-3-cyclooctylguanidine I-XVII formed were tested for their antiviral effect against the influenza virus A/NWS, A-PR8 and A2 Singapore, and further against the viruses NDV, herpes 2, vaccinia and WEE. In the in vivo test against the influenza virus A2 Singapore and herpes simplex 1-(5-bromo-2-dodecyloxybenzoyl)-3-cyclooctylguanidine is more active and less toxic than cyclooctylamine and 1-cyclooctylguanidine.