Collect. Czech. Chem. Commun.
1980, 45, 1410-1418
https://doi.org/10.1135/cccc19801410
Amides of 4,4-bis(4-ethylphenyl)-2,3-dibromo-cis-2-butenoic acid
Jiří Hartla, Jaroslava Chocholoušováa and Miroslav Semonskýb
a Faculty of Pharmacy, Charles University, 501 65 Hradec Králové
b Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3
Abstract
Amides of 4,4-bis(4-ethylphenyl)-2,3-dibromo-cis-2-butenoic acid (III-LI) have been synthetized and administered to animals with experimental tumours. Their antineoplastic effects did not exceed that of the acid I. However, some of the compounds exhibited a more or less selective effect in animals with certain transplantable tumours.
