Collect. Czech. Chem. Commun. 1980, 45, 1299-1300

Preparation of 2- and 2,5-disubstituted 1,3,4-oxadiazoles from tetrazoles and carboxylic acids

František Považanec, Jaroslav Kováč and Jozef Svoboda

Department of Organic Chemistry, Slovak Institute of Technology, 880 37 Bratislava


The intermediate N-acylated tetrazoles, prepared from 5-substituted tetrazoles, N,N'-dicyclohexylcarbodiimide and carboxylic acids, undergo decomposition to form 2-, or 2,5-disubstituted 1,3,4-oxadiazoles in high yield.