Collect. Czech. Chem. Commun. 1980, 45, 901-905

Esters of 1-p-chlorobenzoyl-5-methoxy-2-methyl-3-indolylacetic acid

Ludmila Fišnerová, Vlastimil Rábek and Oldřich Němeček

Research Institute for Pharmacy and Biochemistry, 130 63 Prague 3


Reactions of imidazolide of 1-p-chlorobenzoyl-5-methoxy-2-methyl-3-indolylacetic acid, prepared from the acid and N,N'-carbonyldiimidazole, with the optically active forms of 2-phenyl-3-hydroxypropane acid and with the inactive forms of p-chloro-, p-isopropyl-, and p-isobutyl-2-phenyl-3-hydroxypropane acids gave the corresponding esters. The compounds were tested for antiinflammatory activity.