Collect. Czech. Chem. Commun. 1980, 45, 755-760

Some condensation products of ergoline - I Derivatives with ketones

Jiří Křepelka, Jiří Holubek and Miroslav Semonský

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Monotopic bis-ergolin-2-yl derivatives of alkanes and cycloalkanes (I-VIII) were prepared on reaction of derivatives of ergoline-I (XI-XIV) with ketones in the presence of sulfuric acid or p-toluenesulfonic acid. Esterification of compound XV with cyclohexanol under catalysis with-p-toluenesulfonic acid gave condensation product IX after previous separation of cyclohexyl ester XVI. The condensation products did not exhibit prolactin inhibiting effect.