Collect. Czech. Chem. Commun. 1980, 45, 3370-3377

N-alkylation of 3,5-dicyano-2,4,4,6-tetramethyl-1,4-dihydropyridine with some α,ω-dihalogeno-N-alkenes

Jaroslav Paleček, Jaroslav Kopecký and Josef Kuthan

Department of Organic Technology, Prague Institute of Chemical Technology, 166 28 Prague 6


Bis-1,4-dihydropyridine derivatives Vc-Vf can be obtained on reaction of α,ω-diiodo-n-alkanes with the sodio derivative II of compound I, while α,ω-dibromo-n-alkanes give a mixture of compounds Vc-Vf and IVc-IVf. Analogous products IVa and Va,b could not be prepared, owing to the predominating and disturbing elimination reactions. Spectral characteristics (UV, IR, NMR and mass spectra) of the compounds obtained are confronted with their structure.