Collect. Czech. Chem. Commun. 1980, 45, 3210-3216

Effect of adenosine nucleolipids on the activity of rabbit skeletal muscle protein kinase

Sixtus Hyniea and Jiří Smrtb

a Institute of Pharmacology, Faculty of General Medicine, Charles University, 128 00 Prague 2
b Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


The inhibitory effects of adenosine 5'-phosphate esters with lipoid hydroxy compounds on rabbit skeletal muscle protein kinase are in comparison with adenosine or adenosine 5'-monophosphate relatively weak. The inhibitory effect is in some cases preceded by the enzyme stimulation which can reach up to 70-80% of the stimulation by cyclic AMP. While the inhibitory effect seems to be caused by the adenosine moiety of the compound, the nature of the stimulatory effect is not yet elucidated.