Collect. Czech. Chem. Commun. 1980, 45, 2965-2970

Synthesis of bridgehead chloro-, bromo- and iodobicyclo[2.2.2]octanes

Jan Kopecký and Jaroslav Šmejkal

Institute of Hygiene and Epidemiology, Centre of Occupational Hygiene and Occupational Diseases, 100 42 Prague 10


The paper describes transformations of hydroxy-, acetoxy- or methoxy-bridgehead bicyclo[2.2.2]octanes into bridgehead chloro, bromo or iodo derivatives by action of inorganic halides in the medium of orthophosphoric or polyphosphoric acids.