Collect. Czech. Chem. Commun. 1980, 45, 2714-2723

Analogues of deamino-1-carba-oxytocin with an aliphatic amino acid in position 4: chemical synthesis and biological activities

Michal Lebla, Alena Machováb, Pavel Hrbasa, Tomislav Bartha and Karel Jošta

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Linear octapeptides were prepared by stepwise synthesis in solution. Cyclization by the method of active esters yielded analogues of deamino-1-carba-oxytocin with valine, leucine or isoleucine in position 4 instead of the glutamine residue. The basic pharmacological activities of the analogues were determined; their natriuretic action was lower than that of oxytocin.