Collect. Czech. Chem. Commun. 1980, 45, 2695-2699

Esters of 4,4-bis(4-ethylphenyl)-2,3-dibromo-2-butenoic acid and 7-ethyl-4-(4-ethylphenyl)-2,3-dibromo-1-naphthol

Jiří Křepelka, Jiří Holubek and Miroslav Semonský

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Chloride of 4,4-bis(4-ethylphenyl)-2,3-dibromo-2-butenoic acid (VII), prepared in situ, reacted with aliphatic alcohols and benzyl alcohol with the formation of esters II-VI. Reaction of the chloride VII with aromatic alcohols gave 7-ethyl-4-(4'-ethylphenyl)-2,3-dibromo-1-naphthol (VIII), whose structure was corroborated by IR and 1H NMR spectra. Compounds II-VI and VIII exhibited weaker antineoplastic effects than Edikron (I).