Collect. Czech. Chem. Commun. 1979, 44, 2443-2446
https://doi.org/10.1135/cccc19792443

Selective acylation of hydroxy steroids with acyl cyanides

Miroslav Havel, Jiří Velek, Jan Pospíšek and Milan Souček

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6

Abstract

A mild acylation method of steroid alcohols with acyl cyanides is described. The high sensitivity of benzoyl cyanide toward steric conditions in the neighbourhood of the hydroxyl group was made use of for the separation of epimeric hydroxy steroids.