Collect. Czech. Chem. Commun. 1979, 44, 2243-2249

Products of the acid hydrolysis of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (oxazepam)

Jiří Gaspariča, Jiří Zimáka, Petr Sedmerab, Zdeňka Breberováa and Jiří Volkec

a Faculty of Pharmacy, Charles University, 501 65 Hradec Králové
b Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4
c The J. Heyrovský Institute of Physical Chemistry and Electrochemistry, Czechoslovak Academy of Sciences, 121 38 Prague 2


The acid hydrolysis of oxazepam (Ib) was studied. Under various reaction conditions 6-chloro-4-phenylquinazoline-2-carbaldehyde (V) and the compounds VI and VIII were identified among the products besides the expected 2-amino-5-chlorobenzophenone (IVb).