Collect. Czech. Chem. Commun.
1979, 44, 1671-1675
https://doi.org/10.1135/cccc19791671
Hydrogenation derivatives of rifampicin; Their tritium labelling
Jan Hanuša, Jaroslav Kozela, Josef Beneša and Petr Sedmerab
a Isotope Laboratory of Institutes for Biological Research
b Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4
Abstract
The structures of four rifampicin derivatives obtained by its catalytic hydrogenation were determined by mass and 1H NMR spectroscopy. These are 16,17- and 18,19-dihydrorifampicin, its Δ17,18-isomer and 16,17,18,19-tetrahydrorifampicin. The Δ18,19- and Δ17,18-rifampicins were labelled by tritium.
