Collect. Czech. Chem. Commun. 1979, 44, 1671-1675

Hydrogenation derivatives of rifampicin; Their tritium labelling

Jan Hanuša, Jaroslav Kozela, Josef Beneša and Petr Sedmerab

a Isotope Laboratory of Institutes for Biological Research
b Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4


The structures of four rifampicin derivatives obtained by its catalytic hydrogenation were determined by mass and 1H NMR spectroscopy. These are 16,17- and 18,19-dihydrorifampicin, its Δ17,18-isomer and 16,17,18,19-tetrahydrorifampicin. The Δ18,19- and Δ17,18-rifampicins were labelled by tritium.