Collect. Czech. Chem. Commun. 1979, 44, 946-951

Some 6-substituted derivatives of D-8-cyanomethylergoline-I and D-8-methylergoline-I

Antonín Černý, Jiří Křepelka and Miroslav Semonský

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Compounds III-XX exhibiting antilactation and antinidation effects in tests on rats were prepared on N(6)-alkylation of D-8-cyanomethylergoline-I (I) or D-8-methylergoline-I (II) with corresponding bromo (chloro) derivatives in dimethylformamide. The most distinct prolactin-inhibiting activity was found in compound III.