Collect. Czech. Chem. Commun.
1979, 44, 788-791
https://doi.org/10.1135/cccc19790788
The synthesis of 6-amino-8-hydroxy-4-oxo-2-(4-pentyloxybenzoyl)-5,7-diazaspiro[2.5]octa-5,7-diene-1-carbox-N-cyclopentylamide
Viktor Zikán, Miroslav Semonský and Bohumil Kakáč
Research Institute for Pharmacy and Biochemistry, 130 00 Prague 3
Abstract
Condensation of diethyl 2-methoxycarbonyl-3-(4-pentyloxybenzoyl)-cyclopropane-1,1-dicarboxylate with guanidine gave methyl 6-imino-4,8-dioxo-2-(4-pentyloxybenzoyl)-5,7-diazaspiro[2.5]octane-1-carboxylate (I) which was saponified to corresponding carboxylic acid II. The imidazolide of acid II reacted with cyclopentylamine to afford 6-amino-8-hydroxy-4-oxo-2-(4-pentyloxybenzoyl)-5,7-diazaspiro[2.5]octa-5,7-diene-1-carbox-N-cyclopentylamide (III). Compound III when applied per os prolonged the life of animals with some transplanted tumours.
