Collect. Czech. Chem. Commun. 1979, 44, 424-428

7-(3-Substituted amino-2-hydroxypropyl)-8-hydroxymethyltheophyllines

Ladislav Štibrányi, Alfonz Rybár, Lýdia Božeková and Sven Rippa

Drug Research Institute, 801 00 Bratislava


N-Substituted derivatives of 7-(3-amino-2-hydroxypropyl)-8-hydroxymethyltheophylline II were prepared by addition of the respective amines to 7-epoxypropyl-8-hydroxymethyltheophylline (I) and alternatively, by alkylation of the potassium salt of 8-hydroxymethyltheophylline (IIIb) with substituted 1-amino-3-chloro-2-propanols. Compounds II were tested on peripheral vasodilating activity in vitro.